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Observe Carefully (two)diazepam will enhance the degree or influence of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism.apalutamide will minimize the extent or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 in